Research Suggests Cannabis Modifies Sperms’ Genetic Profile

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Research Suggests Cannabis Modifies Sperms’ Genetic Profile


A new Duke Health study indicates that marijuana or cannabis can transmute the genomic lineation of the men’s sperm and could likewise probably affect children too.

Cannabis is a controversial issue and while some countries accept it for medicinal purposes, the research never stops studying the implication of tetrahydrocannabinol (THC). Experiments conducted in rats and a study involving 24 men discovered that the potent substance seems to go after genes in two key cellular pathways. It changes  DNA methylation, a vital procedure to achieve normal development.

Study senior author Scott Kollins revealed, “What we have found is that the effects of cannabis use on males and their reproductive health are not completely null, in that there’s something about cannabis use that affects the genetic profile in sperm.”

Those people who smoked marijuana or weed are identified by the research as regular users. They use it at least weekly for the preceding six months. These cannabis users’ sperm was likened to those who did not smoke it in the past half year and not over 1o times in their generations. The research was published in the journal, Epigenetics.

Martin Alonso/Flcikr

Based on the findings, men with higher THC concentration in their urine means the genetic alteration in their sperm will be more prominent. It appears that the cannabis substance affects hundreds of various genes both in rats and humans. However, several of the genes have something in common and were correlated with two of the exact primary cellular routes. The first one is crucial for organs to reach full size while the other one has a major role in cancer and destroying tumors.

The Duke researchers consider to pursue its study with bigger groups. They want to find out if changes in the men’s sperms could be reversed when they stop smoking weed. Also, they hope to examine the babies’ umbilical cord blood born to fathers whose sperms are modifed by THC. They aim to distinguish if there are any epigenetic alterations are carried on with the child.

Meanwhile, Health Canada has recommended some guidelines regarding the way cannabis edibles and extracts should be sold in the nation. This includes the hard cap on the amount of THC that each product must contain. Health Canada is the government’s department responsible for the nation’s public health.

According to the department, there will be a cap of 10 mg of THC per package of edibles. Extracts shall be restricted to 10 mg of THC per unit and should not exceed more than 1,000 mg in a package. Topicals, on the other hand, like lotions will be confined to 1,000 mg or one gram of THC for every package.

Cannabis-Infused Medicated Oils/Flickr

The edibles are described as products that consist cannabis consumed exactly like food and beverages. Extracts are products produced by extraction process or by fusing phytocannabinoids including vape pens. Topical products are those used on skin, nails, or hair. Although cannabis oil products are legally sold throughout Canada, these will also be covered within the particular product classes.

Their main objective is to safeguard public health with a wrapper that doesn’t interest youth and lessens the consequences of over-consumption. The Liberal administration noted that aside from advocating public safety, they wanted to ward off criminals and organized crimes from getting profit.

Marijuana Cookies/WikimediaCommons

Edible products will be contained in plain packaging and labeling provisions for cannabis merchandise currently on the market. It will also encompass the typical cannabis symbol, health advice, THC listing, CBD content, as well as child-proof packaging.

Based on the recommended measures:

– Edibles need to have a stable shelf-life without the need for refrigeration or freezing.

– Edibles should provide consumers with nutritional details such as ingredients and a date it is best consumed.

– The extracts may consist of flavoring agents. However, the incorporation of sugar, sweetening agents, and sweeteners are prohibited.

– The label of cannabis extracts should not contain flavors that entice youth like dessert or confectionery flavors.

– There is also a restriction on the use of meat, fish, and poultry provided that is dried by an authorized person or dispensary under provincial or territorial law.

– Other forms that threaten health like eyedrops or needles will be banned.

The edibles can be legally sold in Canada not later than Oct. 17, 2019. The department will release the official draft protocols for marijuana on Dec. 22, 2018. The duration of the public consultation will be open up to Feb. 20, 2019.


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2018-12-21T09:23:45+00:00

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